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Evidence-Based Medicine

Formulating Clinical Questions

Asking a clinical question involves creating a PICO or PICOTT question

P patient, population and/or problem

I intervention, prognostic factor, exposure

C comparison, or comparative intervention (if appropriate)- this could also be the absence of intervention or exposure

O outcome you would like to measure or achieve

T type of question you are asking

T type of study you would want to find

Connecting a Research Question to Study Design

Type of Question

Study Design for Question*

Example

Therapy

RCT (randomized controlled trial)

Is this intervention more effective than another?

Diagnostic test

Independent, prospective blind comparison to a gold standard

How accurate is this diagnostic test?

Prognosis

Cohort study à case-control à case series

What is the likely outcome, progression, or survival time for this condition?

Harm/Etiology

**RCT à cohort study à case-control à case series

What are the possible causes of this condition or state of affairs?

Prevention

RCT à cohort study à case-control

How to reduce the risk of this disease?

 

Using Clinical Queries, you can specify the type of question to narrow the study design results. These can be found in both CINAHL in the filters and PubMed Clinical Queries. 

Evidence-Based Medicine

What is EBM?

Evidence-based medicine (EBM) is the integration of best research evidence with clinical expertise and patient values.

  • Best research evidence
  • Clinical expertise
  • Patient values

When these three elements are integrated, clinicians and patients form a diagnostic and therapeutic alliance which optimizes clinical outcomes and quality of life.

From: The Centre for Evidence-Based Medicine (CEBM)

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